卡托普利可抑制猫和大鼠对外周交感神经激活的升压反应。

Captopril inhibits pressor responses to peripheral sympathetic nerve activation in cats and rats.

Boura A L, Hui S C, Rechtman M P, Walters W A

Clin Exp Pharmacol Physiol Suppl. 1982;7:123-8.

Abstract

In cats, under chloralose anaesthesia, captopril (0.1-0.3 mg/kg i.v.) inhibited the potentiation of the pressor effects of the ganglion stimulant McNeil-A-343 caused by intravenous infusion of angiotensin I (0.1 microgram/min). 2. In both cats and rats under chloralose anaesthesia captopril (0.01-1.0 mg/kg i.v.) depressed pressor responses to McNeil-A-343 whilst not modifying those to bilateral occlusion of the carotid arteries, or intravenous injection of the ganglion stimulant dimethylphenylpiperazinium or adrenaline. 3. It is concluded that in the cat and rat captopril depresses cardiovascular responses to sympathetic postganglionic nerve activation, both in the presence and absence of exogenous angiotensin I by an action which is proximal to the terminal synapse.

摘要

在猫身上，水合氯醛麻醉下，卡托普利（静脉注射0.1 - 0.3毫克/千克）抑制了静脉输注血管紧张素I（0.1微克/分钟）所引起的神经节兴奋剂麦克尼尔 - A - 343升压作用的增强。2. 在水合氯醛麻醉的猫和大鼠中，卡托普利（静脉注射0.01 - 1.0毫克/千克）抑制了对麦克尼尔 - A - 343的升压反应，同时不改变对双侧颈总动脉闭塞、静脉注射神经节兴奋剂二甲基苯基哌嗪或肾上腺素的升压反应。3. 得出的结论是，在猫和大鼠中，卡托普利通过在终末突触近端的作用，抑制了对交感神经节后神经激活的心血管反应，无论是否存在外源性血管紧张素I。