Walter A, Walter S
Thorax. 1982 Sep;37(9):699-702. doi: 10.1136/thx.37.9.699.
The density and percentage of degranulated cells of the mast cell population were studied in the isolated lungs of 25 monkeys (Macaca radiata radiata) before and after acute exposure to cigarette smoke. In each animal one lung was used as the test lung while the other lung was used as its control. In the control lungs the total mean mast cell count was 9.5/mm2 and the proportion of degranulated cells was 9.7%. In the lungs exposed to smoke the total counts were lower (7.3/mm2) and the percentage of degranulated cells higher (15.8%). These differences were statistically significant (p less than 0.01) and show that after acute exposure to cigarette smoke there is a degranulation of lung mast cells. Since degranulation is accompanied by local release of histamine, which could act on the smooth muscle of the airways, it is suggested that this may be a mechanism by which smoking-induced acute bronchoconstriction is mediated.
在25只恒河猴（Macaca radiata radiata）急性暴露于香烟烟雾前后，对其离体肺脏中肥大细胞群体的脱颗粒细胞密度和百分比进行了研究。每只动物的一侧肺作为试验肺，另一侧肺作为对照肺。对照肺中肥大细胞的总平均计数为9.5/mm²，脱颗粒细胞比例为9.7%。暴露于烟雾的肺中，总计数较低（7.3/mm²），脱颗粒细胞百分比更高（15.8%）。这些差异具有统计学意义（p小于0.01），表明急性暴露于香烟烟雾后肺肥大细胞会发生脱颗粒。由于脱颗粒伴随着组胺的局部释放，而组胺可作用于气道平滑肌，因此有人提出这可能是吸烟诱导急性支气管收缩的一种介导机制。
