[用5-氮杂胞苷处理非病毒产生性红白血病细胞系（HFL/b）后诱导感染性弗氏病毒]
[Induction of infectious Friend virus after treatment with 5-azacytidine of a non-virus-producing erythroleukemia line (HFL/b)].
作者信息
Sola B, Pozo F, Martial M A, Chabert-Gisselbrecht S
出版信息
C R Seances Acad Sci III. 1982 Nov 22;295(10):615-8.
PMID:6186347
Abstract
A Friend virus induced erythroleukemia cell line (HFL/b cells) did not produce infectious MuLV and only expressed the defective SFFV component of Friend virus (SFFV (+), F-MuLV (-)). This line temporarily produced infectious F-MuLV following 5 azacytidine treatment. These results suggest that the F-MuLV expression is specifically repressed in these cells by a mechanism which does not affect the F-MuLV related SFFV genome.
摘要
一种由Friend病毒诱导的红白血病细胞系（HFL/b细胞）不产生传染性鼠白血病病毒（MuLV），仅表达Friend病毒的缺陷型脾集落形成病毒成分（SFFV(+)，F-MuLV(-)）。该细胞系在经5-氮杂胞苷处理后可短暂产生传染性F-MuLV。这些结果表明，在这些细胞中，F-MuLV的表达通过一种不影响与F-MuLV相关的SFFV基因组的机制受到特异性抑制。
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