Kuhajda F P, Taxy J B
Arch Pathol Lab Med. 1983 May;107(5):239-42.
Sacrococcygeal teratoma (SCT) is an uncommon tumor that primarily occurs in female infants. Histologic assessments of these neoplasms for immature neuro-epithelial elements and malignant germ cell components correlate with recurrence and metastases, respectively. In this report of 15 SCTs, in addition to routine histologic evaluation the tumors were studied for the presence of carcinoembryonic antigen (CEA), alpha-fetoprotein (AFP), and human chorionic gonadotropin (HCG) by the immunoperoxidase method. Both CEA and AFP were commonly (82% and 53%) present in benign epithelium of these teratomas. In three cases, a germ cell component was identified in which two were focally positive for both CEA and AFP. Although presence of these antigens did not correlate with tumor grade, immunoperoxidase for oncofetal antigens may be useful in predicting which serum marker to measure in patients with suspected recurrent teratoma.
骶尾部畸胎瘤（SCT）是一种罕见的肿瘤，主要发生于女婴。对这些肿瘤进行组织学评估，以确定其中未成熟神经上皮成分和恶性生殖细胞成分，这分别与复发和转移相关。在这份关于15例骶尾部畸胎瘤的报告中，除了进行常规组织学评估外，还采用免疫过氧化物酶法对肿瘤进行癌胚抗原（CEA）、甲胎蛋白（AFP）和人绒毛膜促性腺激素（HCG）检测。CEA和AFP在这些畸胎瘤的良性上皮中普遍存在（分别为82%和53%）。在3例病例中，发现了生殖细胞成分，其中2例CEA和AFP均呈局灶性阳性。虽然这些抗原的存在与肿瘤分级无关，但检测肿瘤胎儿抗原的免疫过氧化物酶法可能有助于预测疑似复发性畸胎瘤患者应检测哪种血清标志物。
