Young A P, Gunning P W, Landreth G E, Ignatius M, Shooter E M
Birth Defects Orig Artic Ser. 1983;19(4):33-46.
Cessation of cell division and DNA synthesis are not required for beta NGF-induced neurite outgrowth from PC12 cells. However, beta NGF-mediated increases in RNA and protein levels closely correlate with the size and number of neurites per cell suggesting that these changes influence some quantitative aspects of neurite outgrowth. RNA levels are increased due to an increase in transcriptional rates. It is likely that the increase in transcription is triggered by the beta NGF-mediated increase in the amounts of the nucleoside triphosphates which serve as substrates for transcription.
β-神经生长因子（β-NGF）诱导PC12细胞长出神经突并不需要细胞分裂和DNA合成的停止。然而，β-NGF介导的RNA和蛋白质水平的增加与每个细胞的神经突大小和数量密切相关，这表明这些变化影响了神经突生长的一些定量方面。RNA水平的增加是由于转录速率的提高。转录的增加很可能是由β-NGF介导的作为转录底物的核苷三磷酸量的增加所触发的。
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