用沉淀抗体和类固醇释放抗体验证雌激素受体的共同核心假说。

Validation of the common-core hypothesis of estrogen receptors with precipitating and steroid-releasing antibodies.

作者信息

Hekim N, Meyer H H, Szendro P I, Jungblut P W

出版信息

Hoppe Seylers Z Physiol Chem. 1983 Jun;364(6):769-75. doi: 10.1515/bchm2.1983.364.1.769.

DOI:10.1515/bchm2.1983.364.1.769

PMID:6193049

Abstract

The immunoglobulin G fraction of a goat antiserum raised against a presumed endoglycosidase-fission product of estradiol receptor from porcine uteri contains some antibodies which precipitate the estradiol/receptor complex and others which release the steroid from the protein. Subcellular receptor forms and receptors from different porcine target organs react in the same fashion as do human, ovine, bovine, guinea pig, rabbit and rat estradiol receptors.

摘要

用针对猪子宫雌激素受体假定的内切糖苷酶裂解产物制备的山羊抗血清的免疫球蛋白G组分，含有一些能沉淀雌激素/受体复合物的抗体，以及另一些能从蛋白质上释放类固醇的抗体。亚细胞受体形式以及来自不同猪靶器官的受体，与人类、绵羊、牛、豚鼠、兔和大鼠的雌激素受体反应方式相同。