氯化锰增强小鼠自然杀伤细胞活性

Augmentation of murine natural killer cell activity by manganese chloride.

作者信息

Rogers R R, Garner R J, Riddle M M, Luebke R W, Smialowicz R J

出版信息

Toxicol Appl Pharmacol. 1983 Aug;70(1):7-17. doi: 10.1016/0041-008x(83)90174-6.

PMID:6193612

Abstract

Natural killer (NK) cell activity of spleen cells from male CBA/J mice was augmented by a single parenteral injection of MnCl2 administered 1 day prior to testing by in vitro and in vivo isotope release assays. Increased cytotoxic activity was observed in vitro against both NK-sensitive (YAC-1) and NK-resistant (EL-4) target cells. NK activity was also enhanced in normally low (A/J) and intermediately (C57Bl/6J) reactive strains of mice. Augmentation of NK activity by MnCl2 was accompanied by an increase in circulating interferon (IFN) levels.

摘要

通过体外和体内同位素释放试验检测发现，在检测前1天经单次腹腔注射氯化锰后，雄性CBA/J小鼠脾细胞的自然杀伤（NK）细胞活性增强。在体外观察到对NK敏感（YAC-1）和NK抗性（EL-4）靶细胞的细胞毒性活性均增加。在通常NK活性较低的（A/J）和中等反应性的（C57Bl/6J）小鼠品系中，NK活性也增强。氯化锰增强NK活性的同时，循环干扰素（IFN）水平也升高。