中缝核损伤后大鼠纹状体中[3H]埃托啡的结合

[3H]etorphine binding in rat striatum following lesions of the raphe nuclei.

作者信息

Mashal R D, Owen F, Deakin J F, Poulter M, Slater R

出版信息

Eur J Pharmacol. 1983 Jul 15;91(1):119-21. doi: 10.1016/0014-2999(83)90372-2.

PMID:6193968

Abstract

Following 5,7-dihydroxytryptamine lesions of the rat raphe nuclei a significant reduction in striatal serotonin concentrations was observed. However, with [3H]etorphine as ligand no change in opiate receptor binding was observed in striatal membranes. Moreover, when [3H]etorphine binding was resolved into its mu- and delta + kappa-components no change in either component was observed compared with controls. It is concluded that opiate receptors are not on striatal serotonergic nerve terminals whose cell bodies are located in the raphe nuclei.

摘要

在大鼠中缝核经5,7 - 二羟基色胺损伤后，观察到纹状体中血清素浓度显著降低。然而，以[³H]埃托啡作为配体时，未观察到纹状体膜中阿片受体结合有变化。此外，当将[³H]埃托啡结合解析为其μ和δ + κ组分时，与对照组相比，两个组分均未观察到变化。得出的结论是，阿片受体不在细胞体位于中缝核的纹状体5-羟色胺能神经末梢上。