干扰素作用机制III——pppA2'p5'A2'p5'A在干扰素抗病毒作用中的意义

Mechanism of interferon action III--significance of pppA2'p5'A2'p5'A in the antiviral action of interferon.

作者信息

Liu X Y, Yao K, Zhou Y X, Jin J R, Wen Y M, Lou Y C, Li B L, Wang D B

出版信息

Sci Sin B. 1983 Aug;26(8):809-17.

PMID:6194560

Abstract

This paper is to evidence that the antiviral effect of pppA2'P5'A2'P5'A(2'-5'P3A3) could cover a wide spectrum of viruses, the RNA viruses such as influenza H3N2/77, influenza H1N1/77, ECHO11, rhino, Sendai, Sindbis and VSV, and the DNA viruses such as herpes (type I). In addition, the antiviral effect of 2'-5'P3A3 on ECHO11 virus, as compared with other viruses, is more efficient than that of IFN. It seems likely that 2'-5'P3A3 plays an important role in the antiviral action of IFN. After comparing the action of 2'-5'P3A3 with interferon (IFN), it has appeared that the action of 2'-5'P3A3 is something parallel to that of IFN for most viruses. For a few viruses, however, considerable differences have been observed.

摘要

本文旨在证明pppA2'P5'A2'P5'A(2'-5'P3A3)的抗病毒作用可涵盖多种病毒，包括RNA病毒，如H3N2/77流感病毒、H1N1/77流感病毒、ECHO11病毒、鼻病毒、仙台病毒、辛德比斯病毒和水疱性口炎病毒，以及DNA病毒，如I型疱疹病毒。此外，与其他病毒相比，2'-5'P3A3对ECHO11病毒的抗病毒作用比干扰素更有效。2'-5'P3A3似乎在干扰素的抗病毒作用中起重要作用。在比较了2'-5'P3A3与干扰素（IFN）的作用后，发现对于大多数病毒，2'-5'P3A3的作用与IFN的作用相似。然而，对于少数病毒，观察到了相当大的差异。