一种可能的新的人类白细胞抗原-DR等位基因。

A possible new HLA-DR allele.

作者信息

Betuel H, Gebuhrer L, Lambert J, Freidel A C, Farre A

出版信息

Hum Immunol. 1983 Nov;8(3):227-37. doi: 10.1016/0198-8859(83)90040-x.

PMID:6196341

Abstract

In routine screening of anti-HLA DR reagents, serum 901 was obtained from a woman of negroid origin ten days after delivery of a second child. The spouse was also of black origin. This serum contained polyspecific HLA A and B antibodies. After platelet absorption it reacted with the B cells of 10 out of 119 European Caucasoid panel donors (8.4%) typed for DR1 to DRW10 and for MT1, MT2. Each of these ten donors had only one recognized DR antigen, the other was "blank." Serum 901 gave negative reactions with the homozygous typing cells (HTC) DW1 to DW8. In 18 normal informative Caucasoid families, serum 901 recognized one HLA haplotype in one (or both) parents and segregated with this haplotype in one or more than one child. In one family in which both parents reacted with serum 901, two children were homozygous for this marker and reacted as HTCs. One of these HTCs typed as DW9 and was found to be identical to a DW9.HTC (8W207).

摘要

在抗HLA DR试剂的常规筛查中，901号血清取自一名黑人血统的女性，这是她在产下第二个孩子十天后提供的。其配偶也是黑人血统。该血清含有多特异性HLA A和B抗体。经血小板吸收后，它与119名欧洲白种人供者中的10名（8.4%）的B细胞发生反应，这些供者针对DR1至DRW10以及MT1、MT2进行了分型。这十名供者每人仅有一种可识别的DR抗原，另一个为“空白”。901号血清与纯合分型细胞（HTC）DW1至DW8呈阴性反应。在18个正常信息丰富的白种人家庭中，901号血清在一位（或两位）父母中识别出一种HLA单倍型，并在一个或多个孩子中与该单倍型分离。在一个父母双方均与901号血清发生反应的家庭中，两个孩子对该标记呈纯合状态，并表现为HTC。其中一个HTC分型为DW9，且被发现与一个DW9.HTC（8W207）相同。