血小板表面抗原：单克隆抗体分析。I. 抗体。I. 免疫学和生物化学研究。

Platelet surface antigens: analysis by monoclonal antibodies. I. Antibodies. I. Immunological and biochemical studies.

作者信息

Santoso S, Lohmeyer J, Rennich H, Clemetson K J, Mueller-Eckhardt C

出版信息

Blut. 1984 Mar;48(3):161-70. doi: 10.1007/BF00320339.

DOI:10.1007/BF00320339

Abstract

Monoclonal antibodies were produced against human platelets. Four antibodies (PA1, PA2, PA3 and PA4) reacted specifically with platelets and megakaryocytes, but not with peripheral blood lymphocytes, granulocytes, erythrocytes or monocytes. The antibodies belonged to the mouse IgG subclass 2a (PA1, PA2, PA3), or 1 (PA4) respectively. PA1 and PA4 did not precipitate, their antigens have not yet fully been characterized. PA3 was directed against the glycoprotein (Gp) complex IIb/IIIa; PA2 precipitated Gp IIb/IIIa, and, in addition, Gp Ia. PA4 revealed specificity against the human platelet alloantigen Zw(a).

摘要

制备了抗人血小板的单克隆抗体。四种抗体（PA1、PA2、PA3和PA4）与血小板和巨核细胞发生特异性反应，但与外周血淋巴细胞、粒细胞、红细胞或单核细胞无反应。这些抗体分别属于小鼠IgG亚类2a（PA1、PA2、PA3）或1（PA4）。PA1和PA4不沉淀，其抗原尚未完全鉴定。PA3针对糖蛋白（Gp）复合物IIb/IIIa；PA2沉淀Gp IIb/IIIa，此外还沉淀Gp Ia。PA4显示出对人血小板同种抗原Zw(a)的特异性。

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