顺二氨合铂（II）-聚谷氨酸复合物治愈小鼠刚果锥虫感染的能力。
Capacity of a cis-diammineplatinum[II]-polyglutamic acid complex to cure Trypanosoma congolense infections in mice.
作者信息
Meshnick S R, Brown D, Smith G
出版信息
Antimicrob Agents Chemother. 1984 Feb;25(2):286-8. doi: 10.1128/AAC.25.2.286.
Abstract
A cis-diammineplatinum(II)-polyglutamic acid complex proved to have marked trypanocidal activity in vivo. When 5 mg of platinum per kg was administered daily for 5 days or when 20 mg of platinum per kg was administered on days 1, 3, and 6, five of five treated Trypanosoma congolense-infected mice were cured. In contrast, cis-platin was ineffective at all doses tested. We believe that the complex has a much higher therapeutic ratio than does uncomplexed drug because it is less toxic.
摘要
顺二氨合铂（II）-聚谷氨酸复合物在体内显示出显著的杀锥虫活性。当以每千克5毫克铂的剂量每日给药5天，或在第1、3和6天以每千克20毫克铂的剂量给药时，五只感染刚果锥虫的小鼠经治疗后全部治愈。相比之下，顺铂在所有测试剂量下均无效。我们认为该复合物的治疗指数比未复合的药物高得多，因为它的毒性较小。
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本文引用的文献
1
Trypanocidal activity of daunorubicin and related compounds.柔红霉素及相关化合物的杀锥虫活性。
Nature. 1981 Jul 30;292(5822):466-7. doi: 10.1038/292466a0.
2
Cure of mice infected with Trypanosoma rhodesiense by cis-diamminedichloroplatinum (II) and disulfiram rescue.
Science. 1982 Jul 30;217(4558):454-6. doi: 10.1126/science.7201165.
3
Isolation of salivarian trypanosomes from man and other mammals using DEAE-cellulose.使用二乙氨基乙基纤维素从人和其他哺乳动物中分离涎源性锥虫。
Exp Parasitol. 1970 Dec;28(3):521-34. doi: 10.1016/0014-4894(70)90120-7.
4
New platinum complexes with anti-tumour activity.
Chem Biol Interact. 1972 Nov;5(6):415-24. doi: 10.1016/0009-2797(72)90078-6.
5
Activity of antitumor drugs against African trypanosomes.抗肿瘤药物对非洲锥虫的活性。
Antimicrob Agents Chemother. 1979 Feb;15(2):157-60. doi: 10.1128/AAC.15.2.157.
6
The mechanism of action of antitumor platinum compounds.抗肿瘤铂化合物的作用机制。
Prog Nucleic Acid Res Mol Biol. 1979;22:71-133. doi: 10.1016/s0079-6603(08)60799-0.
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