Feuerstein G, Helke C, Faden A I
Brain Res. 1984 May 23;300(2):305-10. doi: 10.1016/0006-8993(84)90840-0.
Concentrations of immunoreactive substance P ( SPir ) and immunoreactive somatostatin ( SSir ) were determined in discrete brain nuclei of normal rats and rats exposed to acute hypovolemic hypotension (8 ml/300 g body weight). SPir in the hypothalamic paraventricular nucleus (PVN) and the caudal and rostral parts of the nucleus of the tractus solitarius (NTS) were significantly reduced 2 h after hemorrhage, but no changes were found in any of the brain nuclei when examined 5 min after the same bleeding. SSir in the NTS and nucleus ambiguus (NA) were reduced by 50-60% 2 h after the hemorrhage, as compared either to intact rats or rats examined 5 min after bleeding. In the forebrain, significantly lower concentrations of SSir were found in the nucleus supraopticus at both 5 min and 2 h after shock and in the PVN of rats 2 h after shock. These data suggest a role for SPir and SSir in central adaptation to hypovolemic hypotension and further indicate that functions regulated by these neuropeptides might be substantially affected by shock states.
在正常大鼠以及经历急性低血容量性低血压（8毫升/300克体重）的大鼠的离散脑核团中，测定了免疫反应性P物质（SPir）和免疫反应性生长抑素（SSir）的浓度。出血后2小时，下丘脑室旁核（PVN）以及孤束核（NTS）的尾侧和头侧部分的SPir显著降低，但在相同出血后5分钟检查时，任何脑核团均未发现变化。与完整大鼠或出血后5分钟检查的大鼠相比，出血后2小时，NTS和疑核（NA）中的SSir降低了50 - 60%。在前脑，休克后5分钟和2小时视上核以及休克后2小时大鼠PVN中的SSir浓度显著降低。这些数据表明SPir和SSir在中枢适应低血容量性低血压中发挥作用，并进一步表明这些神经肽调节的功能可能受到休克状态的显著影响。
