Green I, Kumagai S, Steinberg A D
Arthritis Rheum. 1982 Jul;25(7):824-7. doi: 10.1002/art.1780250722.
Purified T cells from normal subjects and patients with systemic lupus erythematosus (SLE) were studied for their abilities to respond to hapten modified self antigens and to antigens on autologous non T cells. Primary and secondary proliferative T cell responses to trinitrophenyl modified (TNP) non T cells were markedly impaired in patients with active SLE as compared with normal subjects or patients with inactive SLE. In contrast, patients with active SLE had significantly stronger cytotoxic activity against TNP modified autologous non T cells. Patients with active SLE had impaired proliferative responses to nonmodified autologous non T cells (auto-MLR). A significant negative correlation was observed between the degree of the auto-MLR and the degree of cytotoxic ability against TNP modified autologous cells in patients with SLE. This observation suggests that cells capable of proliferating in the auto-MLR might regulate the generation of cytotoxic T cell responses against modified self. We then analyzed the ability of anti T cell antibodies from patients with active SLE to preferentially interfere with this naturally occurring suppressor T cell function.
对来自正常受试者和系统性红斑狼疮（SLE）患者的纯化T细胞进行研究，以观察它们对半抗原修饰的自身抗原以及自体非T细胞上抗原的反应能力。与正常受试者或非活动期SLE患者相比，活动期SLE患者对三硝基苯基修饰（TNP）的非T细胞的初次和二次增殖性T细胞反应明显受损。相反，活动期SLE患者对TNP修饰的自体非T细胞具有显著更强的细胞毒性活性。活动期SLE患者对未修饰的自体非T细胞（自身混合淋巴细胞反应，auto-MLR）的增殖反应受损。在SLE患者中，观察到自身混合淋巴细胞反应的程度与对TNP修饰的自体细胞的细胞毒性能力程度之间存在显著负相关。这一观察结果表明，能够在自身混合淋巴细胞反应中增殖的细胞可能调节针对修饰自身的细胞毒性T细胞反应的产生。然后，我们分析了活动期SLE患者的抗T细胞抗体优先干扰这种天然存在的抑制性T细胞功能的能力。
