Rambo W M, Del Bene V E, Burkey L G, Collins C D, Richmond D K
Rev Infect Dis. 1982 Nov-Dec;4 Suppl:S683-7.
The efficacy and safety of moxalactam were compared with those of a combination of clindamycin and an aminoglycoside in a randomized study of therapy for 60 patients with the following surgical infections: intraabdominal or pelvic infections (12 patients), abscesses (13 patients), and severe infections of extremities (35 patients). These infections were equally distributed between the two treatment groups, except that, according to the randomization process, a majority of patients with intraabdominal infections received moxalactam therapy. Surgery was used as adjunctive therapy when necessary. One adverse reaction--fever and leukocytosis with eosinophilia--was due to continued administration of moxalactam. No significant adverse reaction was observed in the patients treated with the clindamycin-aminoglycoside combination. Although the number of isolated organisms resistant to the antibiotics was similar within each treatment regimen, an alarmingly high percentage of gram-positive cocci were intermediately sensitive to moxalactam in vitro. Even in the presence of resistant organisms, moxalactam therapy was as effective as the clindamycin-aminoglycoside therapy when surgical debridement or drainage was properly timed and executed.
在一项针对60例患有以下外科感染的患者的随机治疗研究中，比较了拉氧头孢与克林霉素和氨基糖苷类药物联合使用的疗效和安全性：腹腔或盆腔感染（12例患者）、脓肿（13例患者）以及四肢严重感染（35例患者）。这些感染在两个治疗组中均匀分布，但根据随机分组过程，大多数腹腔感染患者接受了拉氧头孢治疗。必要时手术用作辅助治疗。一种不良反应——发热、白细胞增多伴嗜酸性粒细胞增多——是由于持续使用拉氧头孢所致。在接受克林霉素 - 氨基糖苷类药物联合治疗的患者中未观察到明显的不良反应。尽管在每个治疗方案中对这些抗生素耐药的分离菌数量相似，但在体外革兰氏阳性球菌对拉氧头孢中度敏感的比例高得惊人。即使存在耐药菌，当手术清创或引流时机恰当且操作正确时，拉氧头孢治疗与克林霉素 - 氨基糖苷类药物治疗一样有效。
