Crandall E D
Am Rev Respir Dis. 1983 May;127(5 Pt 2):S16-24.
An overall view of the barrier properties of pulmonary alveolar epithelium is beginning to emerge from the recent studies on isolated alveolar epithelial preparations reviewed here. It appears that the alveolar epithelial barrier is normally extremely tight and is probably highly effective in preventing the passive flow of water and solutes into alveoli in normal lungs. It becomes leaky when subjected to a number of insults, suggesting an important mechanism for the development of alveolar pulmonary edema. Alveolar epithelium is also an actively transporting tissue, and, as such, probably plays a major role in normal lung fluid balance. We are just beginning to gain insight into these active and passive transport processes, and a great deal of work remains to be done in order to understand their mechanisms, importance, and regulation in vivo under both normal conditions and conditions involving pulmonary edema.
通过本文所综述的关于分离肺泡上皮制剂的最新研究，肺泡上皮屏障特性的整体情况正逐渐显现。肺泡上皮屏障似乎通常极其紧密，在正常肺中可能非常有效地防止水和溶质被动流入肺泡。当受到多种损伤时，它会变得渗漏，这提示了肺泡肺水肿发生的一个重要机制。肺泡上皮也是一个主动转运组织，因此可能在正常肺液体平衡中起主要作用。我们才刚刚开始深入了解这些主动和被动转运过程，为了理解它们在正常条件和涉及肺水肿的条件下体内的机制、重要性及调节，仍有大量工作要做。
