Bevan P
Neurosci Lett. 1983 Feb 21;35(2):185-9. doi: 10.1016/0304-3940(83)90548-7.
This study reports the changes in the behavioural responsiveness of rats in the "Ungerstedt Model' following repeated injections of apomorphine. The changes in striatal [3H]haloperidol binding coincident with the behavioural responses are also estimated. Following unilateral lesions of the substantia nigra, the number of [3H]haloperidol binding sites in the ipsilateral striatum increase, and this effect correlates with the behavioural effect following a single apomorphine injection. Repeated apomorphine treatment, however, results in a decrease of neuroleptic binding sites in the ipsilateral and contralateral striatum accompanied by increased behavioural responses. Thus repeated apomorphine treatment discriminates the receptor mechanisms involved in the behavioural response from those receptors labelled by neuroleptics.
本研究报告了在“翁格斯泰德模型”中，大鼠反复注射阿扑吗啡后行为反应性的变化。同时还估计了与行为反应同时出现的纹状体[3H]氟哌啶醇结合的变化。在黑质单侧损伤后，同侧纹状体中[3H]氟哌啶醇结合位点的数量增加，且这种效应与单次注射阿扑吗啡后的行为效应相关。然而，反复给予阿扑吗啡治疗会导致同侧和对侧纹状体中抗精神病药物结合位点减少，同时行为反应增强。因此，反复给予阿扑吗啡治疗可区分行为反应中涉及的受体机制与抗精神病药物标记的受体机制。
