汞化合物跨双分子脂质膜的转运：脂质组成、pH值和氯化物浓度的影响。

Transport of mercury compounds across bimolecular lipid membranes: effect of lipid composition, pH and chloride concentration.

作者信息

Bienvenue E, Boudou A, Desmazes J P, Gavach C, Georgescauld D, Sandeaux J, Seta P

出版信息

Chem Biol Interact. 1984 Jan;48(1):91-101. doi: 10.1016/0009-2797(84)90009-7.

Abstract

The use of bimolecular lipid membranes (BLM) as model membrane allows the analysis of the transport of mercury compounds across the lipidic barriers of biological membranes. The results of flux measurements show that two mercury compounds--HgCl2 and CH3HgCl--cross the BLM but the overall permeabilities are dependent on the pH of the aqueous media, and are not apparently influenced by the different phospholipid constituents of the bilayers. On the other hand, electrical measurements show that, function of the chemical speciation, the transport of this metal is done essentially in the neutral form.

摘要

使用双分子脂质膜（BLM）作为模型膜，可以分析汞化合物跨生物膜脂质屏障的运输情况。通量测量结果表明，两种汞化合物——HgCl2和CH3HgCl——能够穿过BLM，但总体渗透率取决于水相介质的pH值，且显然不受双层膜中不同磷脂成分的影响。另一方面，电学测量表明，根据化学形态的不同，这种金属的运输主要以中性形式进行。