Effect of experimental acute renal failure on intrinsic renal tubular secretory clearance of organic cations in rats.

Effect of experimental acute renal failure (EARF) on the intrinsic renal tubular secretory clearance (CLscnint) of tetraethylammonium bromide (TEA) and N1-methylnicotinamide (NMN) was examined in rats treated with glycerol, folate, salicylate, uranium and gentamicin. The values of CLscnint was calculated by an equation incorporating the determinants of the renal clearance (CLr), i.e., renal tubular secretory clearance (CLscnr), glomerular filtration rate (GFR), renal plasma flow (RPF), free fraction of the drug in plasma (fp) and fraction (Freabs) of the drug reabsorbed after filtration and secretion in the urine. In the EARF-rats, the values of CLscnint of NMN and TEA were decreased by 0.017-0.575 times and by 0.005-0.737 times as compared to those of the normal rats, respectively. It was suggested that the decreases in CLscnr of both NMN and TEA were due not to the decrease in RPF, but to that in CLscnint.