Müller U
Schweiz Med Wochenschr. 1983 Dec 31;113(52):1982-8.
The efficacy of immunotherapy (IT) of immediate type allergies is well established but its mode of action is unclear. Indication for IT is based on history confirmed by skin tests, RAST and possibly provocation tests. Nature, severity and duration of allergic symptoms must be considered. IT is especially suitable as a basic treatment of seasonal allergic rhinitis and pollen asthma as well as perennial rhinitis and asthma due to the house dust mite. The value of IT with molds and bacterial vaccines is questionable. With insect venoms IT is well established as a means of preventing anaphylactic reactions to hymenoptera stings. Improvement of IT will be brought about chiefly by better standardization and purification of allergen extracts. The significance of IT with chemically modified allergens and using different modes of application (oral, nasal) cannot be definitely evaluated at present.
速发型过敏免疫疗法（IT）的疗效已得到充分证实，但其作用机制尚不清楚。IT的适应证基于皮肤试验、放射性变应原吸附试验（RAST）以及可能的激发试验所证实的病史。必须考虑过敏症状的性质、严重程度和持续时间。IT特别适合作为季节性变应性鼻炎和花粉性哮喘以及由屋尘螨引起的常年性鼻炎和哮喘的基础治疗方法。用霉菌和细菌疫苗进行IT的价值尚存在疑问。对于昆虫毒液，IT作为预防膜翅目昆虫叮咬引起过敏反应的一种方法已得到充分认可。IT的改进主要将通过更好地标准化和纯化变应原提取物来实现。目前尚不能明确评估使用化学修饰变应原和采用不同应用方式（口服、鼻用）进行IT 的意义。
