经气管内接种荚膜组织胞浆菌酵母细胞后的免疫反应性。
Immune responsiveness following intratracheal inoculation with Histoplasma capsulatum yeast cells.
作者信息
Nickerson D A, Fairclough P
出版信息
Clin Exp Immunol. 1984 May;56(2):337-44.
Splenic in vitro immune responses from C57B1/6 mice have been evaluated after intratracheal (i.t.) or intravenous (i.v.) inoculation with live Histoplasma capsulatum yeast cells. Significant (P less than 0.005) numbers of cells reactive to heat killed H. capsulatum (HK-Hc) were present 1 week after i.t. inoculation with 5 X 10(5) viable yeast cells. In contrast, blastogenic responses to HK-Hc were not detected until 3 weeks after i.v. H. capsulatum inoculation. Examination of non-specific immunity, i.e. mixed lymphocyte responses to alloantigens and antibody formation to sheep erythrocytes, revealed a significant (P less than 0.005) and transient depression of these responses 1 week following i.t. H. capsulatum inoculation. The non-specific decreases associated with early (1 week) i.t. infection were not mediated by suppressor cells but were related to the number of viable yeast administered.
在用活的荚膜组织胞浆菌酵母细胞进行气管内（i.t.）或静脉内（i.v.）接种后，已对C57B1/6小鼠的脾脏体外免疫反应进行了评估。在用5×10⁵个活酵母细胞进行气管内接种后1周，出现了大量（P<0.005）对热灭活荚膜组织胞浆菌（HK-Hc）有反应的细胞。相比之下，直到静脉内接种荚膜组织胞浆菌3周后才检测到对HK-Hc的增殖反应。对非特异性免疫的检查，即对同种异体抗原的混合淋巴细胞反应和对绵羊红细胞的抗体形成，发现在气管内接种荚膜组织胞浆菌1周后，这些反应出现了显著（P<0.005）且短暂的抑制。与早期（1周）气管内感染相关的非特异性降低不是由抑制细胞介导的，而是与所接种的活酵母数量有关。
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