Balfour I C, Covitz W, Davis H, Rao P S, Strong W B, Alpert B S
Am Heart J. 1984 Aug;108(2):345-50. doi: 10.1016/0002-8703(84)90623-9.
Cardiac size and function were studied echocardiographically in 124 children with sickle cell anemia. A group of 78 healthy black children served as control subjects. Sickle cell patients exhibited progressive chamber enlargement and progressively increasing left ventricular mass. Although contractility indices were normal, when the opposing influences of volume overload due to anemia and ventricular dysfunction were separated, abnormalities of systolic time intervals were identified. Left ventricular systolic time interval ratio and left ventricular preejection period were higher in the sickle cell group and became increasingly abnormal with growth, suggesting that left ventricular function deteriorated with time.
对124例镰状细胞贫血患儿进行了超声心动图检查，以研究心脏大小和功能。78名健康黑人儿童作为对照组。镰状细胞病患者表现出逐渐的心室扩大和左心室质量的逐渐增加。尽管收缩性指标正常，但当将贫血导致的容量超负荷和心室功能障碍的相反影响分开时，发现了收缩期时间间隔异常。镰状细胞组的左心室收缩期时间间隔比和左心室射血前期较高，并且随着生长变得越来越异常，提示左心室功能随时间恶化。
