Schneider E, Wohlrab F, Cossel L
Biomed Biochim Acta. 1984;43(5):683-90.
Insulitis can be induced in C57B1/KsJ mice by injection of subdiabetogenic doses of streptozotocin (SZ, 40 mg/kg body weight) on five consecutive days. Subsequent to the resulting insulitis, a persisting diabetes syndrome develops. This experimental diabetes is regarded as a model of insulin-dependent diabetes mellitus in man (IDDM, type I). Insulitis is considered as a cellular immune reaction against the beta cells in the islets of Langerhans. This paper describes an ultrastructural study showing that lymphoid cells destroy the outer membranes of beta cells. No histochemical indications of the presence of T lymphocytes were found. Some of the lymphocytes are characterized as natural killer cells (NK cells) according to their histochemical and ultrastructural features.
通过连续五天注射亚致糖尿病剂量的链脲佐菌素（SZ，40毫克/千克体重），可在C57B1/KsJ小鼠中诱发胰岛炎。在由此产生的胰岛炎之后，会出现持续的糖尿病综合征。这种实验性糖尿病被视为人类胰岛素依赖型糖尿病（IDDM，I型）的模型。胰岛炎被认为是针对胰岛中β细胞的细胞免疫反应。本文描述了一项超微结构研究，表明淋巴细胞会破坏β细胞的外膜。未发现T淋巴细胞存在的组织化学迹象。根据其组织化学和超微结构特征，一些淋巴细胞被鉴定为自然杀伤细胞（NK细胞）。
