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垂体神经叶调节大鼠促肾上腺皮质激素的释放。

Neural lobe of pituitary modulates corticotropin release in the rat.

作者信息

Baertschi A J, Vallet P, Baumann J B, Girard J

出版信息

Endocrinology. 1980 Mar;106(3):878-82. doi: 10.1210/endo-106-3-878.

Abstract

The hypothesis was tested that the neural lobe of the pituitary may modulate the release of anterior pituitary hormones. The neural lobe of anesthetized lactating rats was electrically stimulated at 30 Hz (5 sec on and 5 sec off) for 3 min while taking blood samples for RIA of ACTH. Plasma ACTH increased within 3 min by 22 +/- 9% (average +/- SEM; P less than 0.025) in intact rats and by 38 +/- 17% (P less than 0.025) in rats where the nerve supply to the median eminence and neural lobe was interrupted. Electrical stimulation of the anterior pituitary was ineffective. No significant changes in plasma ACTH were observed in rats with coagulated hypophysial portal vessels or in Brattleboro rats with congenital diabetes insipidus. Apparently, neither peripheral plasma vasopressin (estimated at 150 microU/ml maximum) nor intermediate lobe ACTH could account for the observed rise in ACTH. Results suggest a vasopressin dependent modulation of ACTH release by the neural lobe, mediated either by axon collaterals to the median eminence or by a vascular interconnection between posterior and anterior pituitaries.

摘要

对垂体神经叶可能调节垂体前叶激素释放这一假说进行了检验。在对麻醉的泌乳大鼠的垂体神经叶以30赫兹(开5秒、关5秒)进行电刺激3分钟的同时,采集血样用于促肾上腺皮质激素(ACTH)的放射免疫分析(RIA)。在完整大鼠中,血浆ACTH在3分钟内增加了22±9%(平均值±标准误;P<0.025),在正中隆起和垂体神经叶神经供应被中断的大鼠中增加了38±17%(P<0.025)。对垂体前叶进行电刺激无效。在垂体门脉血管凝固的大鼠或患有先天性尿崩症的布拉特洛维大鼠中,未观察到血浆ACTH有显著变化。显然,外周血浆血管加压素(最高估计为150微单位/毫升)和中间叶ACTH均不能解释所观察到的ACTH升高。结果表明,垂体神经叶对ACTH释放的调节依赖于血管加压素,其介导方式可能是通过向正中隆起的轴突侧支,或者是通过垂体后叶与前叶之间的血管连接。

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