门腔分流对犬和狒狒肝脏胆固醇合成及环磷酸腺苷的影响。
The effect of portacaval shunt upon hepatic cholesterol synthesis and cyclic AMP in dogs and baboons.
作者信息
Francavilla A, Jones A F, Benichou J, Starzl T E
出版信息
J Surg Res. 1980 Jan;28(1):1-7. doi: 10.1016/0022-4804(80)90074-8.
Hepatic cholesterol synthesis, hepatic cyclic AMP, and portal and peripheral insulin and glucagon levels were investigated in nine dogs and three baboons after complete portacaval shunt. Cholesterol synthesis as measured with acetate incorporation was reduced in both species. Hepatic cyclic AMP increased in dogs. Changes in portal and systemic insulin were inconsistent, but hyper-glucagonemia occurred regularly. Diminished hepatic cholesterol synthesis is apparently one factor, although probably not the only one, in the antilipidemic effect of portacaval shunt. This altered cholesterol metabolism may be due to a change in the hormonal environment of the liver caused by portal diversion.
在九只狗和三只狒狒进行完全门腔分流术后，对其肝脏胆固醇合成、肝脏环磷酸腺苷（cAMP）以及门静脉和外周血胰岛素和胰高血糖素水平进行了研究。用醋酸掺入法测定的胆固醇合成在两个物种中均降低。狗的肝脏cAMP升高。门静脉和全身胰岛素的变化不一致，但高胰高血糖素血症经常出现。肝脏胆固醇合成减少显然是门腔分流抗脂血症作用的一个因素，尽管可能不是唯一因素。这种胆固醇代谢的改变可能是由于门静脉分流导致肝脏激素环境的变化。
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