促肾上腺皮质激素样中叶肽（人CLIP）的替代合成。一种与人促肾上腺皮质激素（ACTH）-(18 - 39)序列相对应的肽。
Alternative synthesis of corticotropin-like intermediate lobe peptide (human CLIP). A peptide corresponding to the sequence of human ACTH-(18--39).
作者信息
Turán A, Bajusz S
出版信息
Int J Pept Protein Res. 1980 Feb;15(2):159-66. doi: 10.1111/j.1399-3011.1980.tb02563.x.
Abstract
A novel synthesis of human CLIP, a peptide corresponding to the sequence of human ACTH-(18-39) is described. The dodecapeptide chain was assembled by a combination of fragment condensation and stepwise synthesis while using N alpha-benzyloxycarbonyl and side chain tert.-butyl-derived protective groups combination. The final deprotection was performed by acidolysis in trifluoroacetic acid. The end product was purified by ion exchange chromatography on carboxymethyl cellulose.
摘要
描述了一种新型的人促肾上腺皮质激素样中间肽（CLIP）的合成方法，该肽对应于人促肾上腺皮质激素（ACTH）-（18-39）的序列。使用Nα-苄氧羰基和侧链叔丁基衍生的保护基团组合，通过片段缩合和逐步合成相结合的方式组装十二肽链。最终的脱保护通过在三氟乙酸中进行酸解来完成。终产物通过在羧甲基纤维素上进行离子交换色谱法进行纯化。
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