Tarpey G M, Mendoza S A
J Pharmacol Exp Ther. 1980 Jul;214(1):5-8.
The effects of the oral antidiuretic drug clofibrate on water permeability of the urinary bladder of the toad, Bufo marinus, were studied. Clofibrate did not alter control water flow along an osmotic gradient. Water flow increases due to vasopressin were reversibly inhibited by 1 to 10 mM clofibrate from the serosal side. Clofibrate in the serosal bathing medium inhibited water flow increases due to cyclic AMP but not due to theophylline. Serosal clofibrate concentrations less than 1 mM or clofibrate in the mucosal solution (1 mM) was ineffective in inhibiting the osmotic water permeability response to vasopressin. Clofibrate in the serosal bathing medium (1 mM) inhibited base-line short-circuit current but had no effect on vasopressin-stimulated short-circuit current.
研究了口服抗利尿药物氯贝丁酯对海蟾蜍膀胱水渗透性的影响。氯贝丁酯不会改变沿渗透梯度的对照水流。从浆膜侧加入1至10 mM氯贝丁酯可可逆地抑制因血管加压素引起的水流增加。浆膜浴液中的氯贝丁酯抑制因环磷酸腺苷引起的水流增加，但不抑制因茶碱引起的水流增加。浆膜氯贝丁酯浓度低于1 mM或粘膜溶液中的氯贝丁酯（1 mM）在抑制对血管加压素的渗透水渗透性反应方面无效。浆膜浴液中的氯贝丁酯（1 mM）抑制基线短路电流，但对血管加压素刺激的短路电流没有影响。
