针对爱泼斯坦-巴尔病毒抗原的免疫球蛋白A抗体与鼻咽癌的预后

Immunoglobulin A antibody to Epstein-Barr viral antigens and prognosis in nasopharyngeal carcinoma.

作者信息

Mathew G D, Qualtiere L F, Neel H B, Pearson G R

出版信息

Otolaryngol Head Neck Surg (1979). 1980 Jan-Feb;88(1):52-7. doi: 10.1177/019459988008800115.

DOI:10.1177/019459988008800115

Abstract

IgA immunoglobulin fractions containing antibodies to Epstein-Barr virus (EBV)-induced membrane antigens were isolated from the sera of two patients with nasopharyngeal carcinoma (NPC), from one non-NPC patient, and from three persons with sera negative for IgA antibodies. IgA antibodies were not cytotoxic against cells expressing EBV-induced membrane antigens in the antibody-dependent cellular cytotoxicity (ADCC) assay. However, IgA antibodies blocked IgG-mediated ADCC, which indicated that these antibodies could serve as a blocking "factor" in patients with disease and, therefore, were potentially detrimental to the host.

摘要

从两名鼻咽癌（NPC）患者的血清、一名非NPC患者的血清以及三名IgA抗体呈阴性的人的血清中，分离出了含有针对爱泼斯坦-巴尔病毒（EBV）诱导的膜抗原的抗体的IgA免疫球蛋白组分。在抗体依赖性细胞毒性（ADCC）试验中，IgA抗体对表达EBV诱导的膜抗原的细胞没有细胞毒性。然而，IgA抗体阻断了IgG介导的ADCC，这表明这些抗体在患病患者中可作为一种阻断“因子”，因此可能对宿主有害。