Jahnsen H
Brain Res. 1980 Sep 15;197(1):83-94. doi: 10.1016/0006-8993(80)90436-9.
Cell membrane properties and synaptic transmission were examined by intracellular recording from the CA1 region of hippocampal slices during application of 5-hydroxytryptamine (5-HT). Seventeen cells (50%) showed an inhibitory response to 5-HT. The cells were hyperpolarized with decreased spontaneous activity and increased membrane conductance. The increase may be in potassium or chloride conductance. Synaptic transmission was not involved since Mg2+, Co2+ or Mn2+ did not block the response. 5-HT inhibited dendritic EPSPs by local postsynaptic effect. Four cells (11%) showed an excitatory response. They were depolarized while the spontaneous activity increased and the conductance decreased. The decrease may be in the potassium or chloride conductance. Two cells (6%) showed a mixed type of response with an early excitation and late inhibition. This respons may be a mixture of the two other responses or associated with a third type of 5-HT receptor. Eleven cells (33%) did not respond to 5-HT, but only in 3 of these 5-HT was applied in the soma region. In conclusion, 5-HT may inhibit dendritic excitatory synapses and decrease recurrent inhibition in hippocampus.
在应用5-羟色胺（5-HT）期间，通过对海马切片CA1区进行细胞内记录来检测细胞膜特性和突触传递。17个细胞（50%）对5-HT表现出抑制反应。这些细胞发生超极化，自发活动减少，膜电导增加。这种增加可能是钾电导或氯电导的增加。由于Mg2+、Co2+或Mn2+不能阻断该反应，所以不涉及突触传递。5-HT通过局部突触后效应抑制树突兴奋性突触后电位（EPSP）。4个细胞（11%）表现出兴奋反应。它们发生去极化，同时自发活动增加，电导降低。这种降低可能是钾电导或氯电导的降低。2个细胞（6%）表现出混合类型的反应，早期兴奋，后期抑制。这种反应可能是其他两种反应的混合，或者与第三种类型的5-HT受体有关。11个细胞（33%）对5-HT无反应，但在这11个细胞中只有3个在胞体区域施加了5-HT。总之，5-HT可能抑制海马中的树突兴奋性突触并减少反复抑制。
