抗坏血酸对肾上腺素与新斯的明在神经肌肉传递中相互作用的影响。
The effect of ascorbic acid on the interaction of adrenaline and neostigmine on neuromuscular transmission.
作者信息
Drury P J, Birmingham A T, Healy T E
出版信息
J Pharmacol Methods. 1980 Aug;4(1):89-94. doi: 10.1016/0160-5402(80)90047-9.
Ascorbic acid is used in the laboratory as a stabilizing agent to delay the oxidation of adrenaline solutions. The rat isolated phrenic nerve-diaphragm preparation was used to study the interaction of ascorbic acid, adrenaline and neostigmine on neuromuscular transmission. While ascorbic acid itself did not affect the response of the preparation to phrenic nerve stimulation, it significantly reduced the response of the preparation to neostigmine and the augmentation of this response by adrenaline. The results emphasize the need to consider the consequences of including preservatives or stabilizing agents in drug solutions when quantitative comparisons are made.
在实验室中，抗坏血酸用作稳定剂，以延缓肾上腺素溶液的氧化。采用大鼠膈神经-膈肌标本研究抗坏血酸、肾上腺素和新斯的明对神经肌肉传递的相互作用。虽然抗坏血酸本身并不影响标本对膈神经刺激的反应，但它能显著降低标本对新斯的明的反应以及肾上腺素对该反应的增强作用。这些结果强调，在进行定量比较时，需要考虑药物溶液中添加防腐剂或稳定剂的后果。
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