组胺对豚鼠气管平滑肌中环磷酸腺苷水平的影响。

The effect of histamine on cyclic AMP levels in guinea-pig tracheal smooth muscle.

作者信息

Creese B R, Denborough M A

出版信息

Eur J Pharmacol. 1980 Aug 22;66(1):95-101. doi: 10.1016/0014-2999(80)90299-x.

Abstract

Histamine (10(-5)--3 x 10(-4) M) increased the cylic AMP content of guinea-pig tracheal smooth muscle, the maximal effect being a 3-fold increase after 2-min incubation with 10(-4) histamine. Histamine-induced accumulation of cyclic AMP was not affected by propranolol or atropine, but was reduced by mepyramine. Aspirin and indomethacin abolished the cyclic AMP response to histamine and potentiated histamine-induced contractions of the smooth muscle. These results suggest that the elevation of cyclic AMP levels in response to histamine is mediated by prostaglandins, and represents an important negative feedback regulatory mechanism which modulates the contractile response of guinea-pig tracheal smooth muscle to histamine.

摘要

组胺（10⁻⁵ - 3×10⁻⁴M）可增加豚鼠气管平滑肌中环磷酸腺苷（cAMP）的含量，最大效应是在与10⁻⁴组胺孵育2分钟后增加3倍。组胺诱导的cAMP积累不受普萘洛尔或阿托品的影响，但被美吡拉敏降低。阿司匹林和吲哚美辛消除了对组胺的cAMP反应，并增强了组胺诱导的平滑肌收缩。这些结果表明，组胺引起的cAMP水平升高是由前列腺素介导的，并且代表了一种重要的负反馈调节机制，该机制调节豚鼠气管平滑肌对组胺的收缩反应。