Karliner J S, Barnes P, Brown M, Dollery C
Eur J Pharmacol. 1980 Oct 3;67(1):115-8. doi: 10.1016/0014-2999(80)90017-5.
Compared with sham-operated guinea pigs, chronic heart failure produced by aortic constriction resulted in a 79% increase in alpha 1-adrenoceptor density as measured by [3H]prazosin binding (73 +/- 15 vs. 131 +/- 20 fmol/mg protein, P < 0.05); beta-adrenoceptor number, measured by (-)-[3H]dihydroalprenolol binding, increased by 93% (28 +/- 3.4 vs. 54 +/- 5.2 fmol/mg protein, P < 0.01). For each radioligand KD values were unchanged. Thus, congestive heart failure due to chronic pressure overload results in compensatory augmentation of alpha 1- and beta-adrenoceptor numbers.
与假手术豚鼠相比，主动脉缩窄所致慢性心力衰竭使通过[3H]哌唑嗪结合测定的α1-肾上腺素能受体密度增加79%（73±15对131±20 fmol/mg蛋白质，P<0.05）；通过（-）-[3H]二氢阿普洛尔结合测定的β-肾上腺素能受体数量增加93%（28±3.4对54±5.2 fmol/mg蛋白质，P<0.01）。对于每种放射性配体，KD值未改变。因此，慢性压力超负荷所致充血性心力衰竭导致α1-和β-肾上腺素能受体数量的代偿性增加。
