由铜和苯酚杂质形成的灭活剂对转染性脊髓灰质炎病毒体RNA沉降速率的影响。
Effect of inactivator(s) formed from copper and phenol impurity(ies) on the sedimentation rate of transfective poliovirion RNA.
作者信息
Dubes G R, Al-Moslih M I
出版信息
Arch Virol. 1980;66(1):45-51. doi: 10.1007/BF01315043.
PMID:6254472
Abstract
Transfective poliovirion RNA after inactivation by the inactivator or inactivators formed from copper and an impurity or impurities in reagent-grade phenol sediments more heterogeneously and, on the average, more slowly than intact transfective RNA. The data are consistent with the hypothesis that the inactivator causes scission of the viral RNA molecules.
摘要
经由灭活剂或由铜与试剂级苯酚中的一种或多种杂质形成的灭活剂灭活后，感染性脊髓灰质炎病毒RNA比完整的感染性RNA沉降得更不均匀，且平均沉降速度更慢。这些数据与灭活剂导致病毒RNA分子断裂的假说一致。
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本文引用的文献
1
Inactivation of transfective poliovirion RNA by a product or products of the interaction of trace copper with an impurity or impurities in reagent-grade phenol.痕量铜与试剂级苯酚中的一种或多种杂质相互作用产生的一种或多种产物使感染性脊髓灰质炎病毒RNA失活。
Arch Virol. 1980;66(1):27-44. doi: 10.1007/BF01315042.
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Viral spectrum of an established chimpanzee liver cell line.
Proc Soc Exp Biol Med. 1966 Mar;121(3):824-9. doi: 10.3181/00379727-121-30898.
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