Buryĭ V A, Gurkovskaia A V
Biull Eksp Biol Med. 1980 Nov;90(11):519-21.
Transmembrane ionic currents were investigated in the rabbit pulmonary artery smooth muscle under voltage clamp conditions with the use of the double sucrose gap method. With depolarizing pulses, there developed a fast inactivated outward current that was followed by a steady-state outward current. Tetraethylammonium (TEA) partly suppressed the outward current, and the fast inward current that preceded the fast outward one could be seen in these conditions. Appearance of the fast inward current in TEA-containing solution suggests the overlapping of the fast inward and outward currents. It appears that the resultant transmembrane current has an outward direction since in normal conditions the permeability of the fast potassium channels exceeds that of calcium channels. Conditioning hyperpolarization increased and depolarization decreased the fast outward current indicating that at the resting membrane potential a part of the potassium channels is inactivated and this inactivation is removed by hyperpolarization.
采用双蔗糖间隙法，在电压钳制条件下研究了兔肺动脉平滑肌的跨膜离子电流。在去极化脉冲作用下，出现了快速失活的外向电流，随后是稳态外向电流。四乙铵（TEA）部分抑制了外向电流，在这些条件下可以看到快速外向电流之前的快速内向电流。含TEA溶液中快速内向电流的出现表明快速内向电流和外向电流存在重叠。由于在正常情况下快速钾通道的通透性超过钙通道，因此总的跨膜电流似乎具有外向方向。预处理超极化增加而 depolarization 减少快速外向电流，这表明在静息膜电位时一部分钾通道失活，并且这种失活通过超极化被消除。 （注：原文中“depolarization”未翻译，可能是输入有误，这里保留英文。）
