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保留垂体功能的垂体腺瘤手术治疗(作者译)

[Surgical management of pituitary adenomas with preservation of pituitary function (author's transl)].

作者信息

Wersäll J, Anniko M, Eneroth P, Werner S

出版信息

HNO. 1980 Mar;28(3):80-4.

PMID:6256314
Abstract

Tumors of the pituitary gland comprise a large group of the intracranial tumors. As in all tumor surgery, early diagnosis is essential for the best outcome of treatment. However, the non-functioning adenomas are often diagnosed in their later stages of development as a result of the complexity of symptoms due to a mass lesion. In contrast, hormone-secreting adenomas give early symptoms which can be supported by reliable diagnostic laboratory findings and involve the production of growth hormone, prolactin and ACTH respectively. Using the transantro-sphenoidal route, our results of surgical removal of small tumors have been excellent, and microadenomas have been treated with preservation of normal pituitary function. However, an increasing size of the tumor considerably reduces the possibility of cure.

摘要

垂体肿瘤是颅内肿瘤中的一大类。与所有肿瘤手术一样,早期诊断对于获得最佳治疗效果至关重要。然而,无功能腺瘤由于占位性病变导致症状复杂,往往在疾病发展后期才被诊断出来。相比之下,分泌激素的腺瘤会出现早期症状,这些症状可得到可靠的诊断实验室检查结果的支持,分别涉及生长激素、催乳素和促肾上腺皮质激素的分泌。采用经蝶窦入路,我们手术切除小肿瘤的效果极佳,并且对微腺瘤的治疗能够保留正常垂体功能。然而,肿瘤体积的不断增大显著降低了治愈的可能性。

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