Different patterns of cyclic AMP accumulation in rat corpora lutea after LH stimulation in vitro and in vivo.

Tissue levels of cyclic AMP were measured in rat corpora lutea at various times after administration of LH in vitro and in vivo. In-vitro addition of LH produced more pronounced accumulation of cyclic AMP in very young corpora lutea (1-day-old) than in the older corpora lutea (3- and 7-day-old). When LH was administered in vivo the highest accumulation of cyclic AMP was seen in the older corpora lutea (7- and 3-day-old).