血红蛋白格雷迪的分子基础。
The molecular basis of hemoglobin Grady.
作者信息
Scott A F, Phillips J A, Young K E, Kazazian H H, Smith K D, Charache S, Clegg J B
出版信息
Am J Hum Genet. 1981 Jan;33(1):129-33.
Abstract
DNA from individuals heterozygous for the extended alpha-chain variant Hb Grady were studied by gene counting and restriction enzyme analysis. Neither method indicated the presence of an extra (fifth) alpha gene, which argues that if this variant arose by unequal crossing over, the event most likely involved mispairing between alleles rather than between the separate alpha 1 and alpha 2 loci.
摘要
对携带延长α链变体血红蛋白格雷迪（Hb Grady）的杂合个体的DNA进行了基因计数和限制性酶切分析。两种方法均未表明存在额外的（第五个）α基因，这表明如果该变体是由不等交换产生的，那么该事件最有可能涉及等位基因之间的错配，而不是单独的α1和α2基因座之间的错配。
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