Presynaptic inhibition of transmission from identified interneurons in locust central nervous system.

1. Intracellular recordings near the output terminals of an identified interneuron (the descending contralateral movement detector, DCMD) in the locust revealed the occurrence of depolarizing synaptic potentials. These presynaptic depolarizing potentials were evoked by spikes in both DCMDs, by auditory stimuli, and by electrical stimulation of the pro- to mesothoracic connectives. The occurrence of the depolarizing potentials decreased the amplitude of the action potentials close to the output terminals. 2. The stimuli that produced depolarizing potentials in the presynaptic terminals reduced the amplitude of the monosynaptic excitatory postsynaptic potentials evoked by the DCMDs in identified follower interneurons. We conclude that at least part of this reduction in transmission from the DCMDs results from presynaptic inhibition and that the presynaptic inhibition is related to a reduction in the amplitude of the presynaptic action potentials. 3. We propose that the function of the presynaptic inhibition of the DCMDs is to ensure that the interneurons triggering a jump are never activated by the DCMDs in the absence of proprioceptive signals from the legs indicating the animal's readiness to jump.