Higashida H, Miki N
Nihon Yakurigaku Zasshi. 1981 Feb;77(2):99-113.
This review concerns neuropharmacological properties of clonal cells from tumors in the nervous system and muscle, and/or somatic hybrid cells derived from these clonal preparations. These cells grow well under conditions of culture and show neuronal characteristics identical to those seen in normal cells. Observations of these clonal cells contribute to studies on development, differentiation, synaptogenesis and cellular recognition in the nervous system. Analysis of eukaryotic genes also enables investigations on genetic control mechanisms by which highly differentiated neuronal functions are expressed.
本综述涉及来自神经系统和肌肉肿瘤的克隆细胞以及/或源自这些克隆制剂的体细胞杂种细胞的神经药理学特性。这些细胞在培养条件下生长良好,并表现出与正常细胞相同的神经元特征。对这些克隆细胞的观察有助于神经系统发育、分化、突触形成和细胞识别的研究。真核基因分析还能够对高度分化的神经元功能得以表达的遗传控制机制进行研究。