Black R E, Merson M H, Taylor P R, Yolken R H, Sack D A
Pediatrics. 1981 Jan;67(1):79-83.
The use of oral rehydration solutions containing essential electrolytes and either glucose or sucrose of equal osmolality was compared in a double-blind sequential trial of 784 children with rotavirus-associated diarrhea treated at a center in rural Bangladesh. The oral fluid failure rate was 11.5% for the sucrose-containing solution group and 7.3% for the glucose-containing group (P = NS). Vomiting was a significantly more common cause of failure for the group treated with sucrose-containing oral rehydration solution and was associated with an increased rate of intake of the sweeter sucrose-containing solution. The purging rate was not different for the two groups. The oral fluid failure rates for children in the most underweight category (less than 60% of expected weight for age) were not different from those for other groups, although, as assessed by purging rate and initial dehydration, the stool losses of members of this group constituted a greater proportion of their body weight. Glucose is the preferred carbohydrate for oral electrolyte solutions, although sucrose can be substituted with only minimum loss of efficacy.
在孟加拉国农村一个中心对784名轮状病毒相关性腹泻儿童进行的双盲序贯试验中，比较了含有必需电解质以及等渗葡萄糖或蔗糖的口服补液溶液的使用情况。含蔗糖溶液组的口服补液失败率为11.5%，含葡萄糖组为7.3%（P值无统计学意义）。呕吐是含蔗糖口服补液溶液治疗组更常见的失败原因，且与摄入更甜的含蔗糖溶液的比例增加有关。两组的腹泻率无差异。体重最不足类别（低于年龄预期体重的60%）儿童的口服补液失败率与其他组无差异，不过，从腹泻率和初始脱水情况评估，该组儿童的粪便丢失量占其体重的比例更大。葡萄糖是口服电解质溶液的首选碳水化合物，不过蔗糖替代时疗效仅有极小损失。
