β-肾上腺素能受体激活可诱导豚鼠气管中前列腺素E2的生成。

beta-Adrenoceptor activation induces prostaglandin E2 generation in guinea-pig trachea.

作者信息

Omini C, Folco G, Sautebin L, Nava G, Mandelli V, Berti F

出版信息

Eur J Pharmacol. 1981 Jun 19;72(2-3):227-31. doi: 10.1016/0014-2999(81)90277-6.

Abstract

Isoproterenol and salbutamol caused relaxation of guinea-pig trachea, and generation of PGE2. The phenomenon appears to be specific for beta-adrenergic agonists since the relaxant activity induced by atropine, theophylline and papaverine was not associated with generation of prostaglandin-like material from tracheal smooth muscles. Indomethacin reduced only slightly the relaxation of the tracheal tissue induced by isoproterenol and salbutamol. The possibility is discussed that the increased arachidonic acid metabolism during trachea beta-adrenergic relaxation represents a metabolic event involving phospholipid methylation and membrane fluidity.

摘要

异丙肾上腺素和沙丁胺醇可使豚鼠气管舒张，并生成前列腺素E2。这种现象似乎是β-肾上腺素能激动剂所特有的，因为阿托品、茶碱和罂粟碱诱导的舒张活性与气管平滑肌中前列腺素样物质的生成无关。吲哚美辛仅轻微降低了异丙肾上腺素和沙丁胺醇诱导的气管组织舒张。文中讨论了气管β-肾上腺素能舒张过程中花生四烯酸代谢增加可能代表涉及磷脂甲基化和膜流动性的代谢事件这一可能性。