环磷酸腺苷（cAMP）参与非洲爪蟾卵母细胞减数分裂的细胞质调控。

Involvement of cAMP in the cytoplasmic control of meiotic cell division in Xenopus laevis oocytes.

Godeau F, Schorderet-Slatkine S, Boquet P, Schorderet M, Younglai E V, Baulieu E E

Adv Cyclic Nucleotide Res. 1981;14:421-8.

Abstract

There is a large body of evidence for an inhibitory role for cAMP in progesterone induced meiosis in amphibian oocytes consistent with its known inhibitory activity in mammalian oocytes (5,26). It implies that the action of steroid hormones in this particular tissue is mediated by modifications of cAMP levels within the cell. 2) Bacterial toxins have proved to be useful reagents in the investigation of the regulatory role of cyclic nucleotides in the resumption of cell division in amphibian oocytes. 3) The possible involvement of cGMP in these processes needs to be further investigated.

摘要

有大量证据表明，环磷酸腺苷（cAMP）在两栖类卵母细胞中对孕酮诱导的减数分裂起抑制作用，这与其在哺乳动物卵母细胞中已知的抑制活性一致（5,26）。这意味着类固醇激素在该特定组织中的作用是通过细胞内环磷酸腺苷水平的改变来介导的。2) 细菌毒素已被证明是研究环核苷酸在两栖类卵母细胞细胞分裂恢复中的调节作用的有用试剂。3) 环磷酸鸟苷（cGMP）在这些过程中的可能参与需要进一步研究。