Takashima Y, Hatano T, Tauchi N, Maki T, Uozumi K, Kawamura M
Jpn J Antibiot. 1981 May;34(5):651-4.
A clinical study on cefotiam (CTM) was performed in the field of pediatric infection, and the following results were obtained: The number of cases studied were six including 2 cases of U.T.I., 1 case of vaginitis and vulvitis, 1 cervical lymphadenitis, 1 absence of thigh and coxitis. Clinical responses to CTM were excellent in 3 cases, good in 1 cases but there was 1 exception who dropped out because of concurrent use of other antibiotics. As for bacteriological responses, CTM eliminated the pathogens E. coli and P. mirabilis from U.T.I., Staph. epidermidis and P. morganii, from vaginitis and vulvitis, H influenzae and Str. pneumoniae from cervical lymphadenitis and Staph. aureus from abscess of thigh. No side effect was observed except 1 case who showed an elevation of GOT, GPT and LDH. It is uncertain, however, wether this abnormality was resulted from the use of CTM or not, because the other antibiotics were used also.
在儿科感染领域开展了一项关于头孢替安(CTM)的临床研究,获得了以下结果:研究病例数为6例,包括2例泌尿道感染、1例阴道炎和外阴炎、1例颈部淋巴结炎、1例大腿脓肿和髋关节炎。CTM的临床反应中,3例为优,1例为良,但有1例因同时使用其他抗生素而退出研究。在细菌学反应方面,CTM清除了泌尿道感染中的大肠杆菌和奇异变形杆菌、阴道炎和外阴炎中的表皮葡萄球菌和摩根氏菌、颈部淋巴结炎中的流感嗜血杆菌和肺炎链球菌以及大腿脓肿中的金黄色葡萄球菌。除1例出现谷草转氨酶、谷丙转氨酶和乳酸脱氢酶升高外,未观察到副作用。然而,由于也使用了其他抗生素,尚不确定这种异常是否由CTM的使用所致。