A32390A，一种新的生物活性代谢物。II. 分离与结构
A32390A, a new biologically active metabolite. II. Isolation and structure.
作者信息
Marconi G G, Molloy B B, Nagarajan R, Martin J W, Deeter J B, Occolowitz J L
出版信息
J Antibiot (Tokyo). 1978 Jan;31(1):27-32. doi: 10.7164/antibiotics.31.27.
PMID:627520
Abstract
An inhibitor of dopamine-beta-hydroxylase, designated A32390A, was isolated from the culture broth of a Pyrenochaeta species. The inhibitor showed antimicrobial activity against fungi and gram-positive bacteria. Spectroscopic analysis and chemical degradation studies indicated that the structure was 1,6-di-O-(2-isocyano-3-methylcrotonyl)-D-mannitol.
摘要
从一种柄孢壳菌属物种的培养液中分离出一种多巴胺-β-羟化酶抑制剂，命名为A32390A。该抑制剂对真菌和革兰氏阳性菌具有抗菌活性。光谱分析和化学降解研究表明，其结构为1,6-二-O-(2-异氰基-3-甲基巴豆酰基)-D-甘露醇。
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