Specific adsorbents for affinity chromatography of benzodiazepine binding proteins.
作者信息
Martini C, Lucacchini A, Ronca G
出版信息
Prep Biochem. 1981;11(5):487-99. doi: 10.1080/00327488108065538.
PMID:6280161
Abstract
The use of affinity chromatography as means of isolating/purifying proteins which have an affinity for benzodiazepine is described. Three such drugs are employed: chlorazepate, clonazepam and delorazepam. The results presented in this paper indicate that the proposed technique only works for chlorazepate and delorazepam. In fact these benzodiazepine-Sepharose derivatives are able to retain specifically proteins from human serum and rat kidney, lung, skeletal muscle and brain.
摘要
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