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肾磷酸盐阈浓度（TmPO4/GFR）

Renal threshold phosphate concentration (TmPO4/GFR).

作者信息

Kruse K, Kracht U, Göpfert G

出版信息

Arch Dis Child. 1982 Mar;57(3):217-23. doi: 10.1136/adc.57.3.217.

DOI:10.1136/adc.57.3.217
PMID:6280622
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1627603/
Abstract

The ratio of maximum rate of renal tubular reabsorption of phosphate to glomerular filtration rate (TmPO4/GFR) was determined in 546 schoolchildren, aged between 6 and 17.9 years, using the nomogram of Walton and Bijvoet.1 TmPO4/GFR correlated with chronological age in girls and boys and in each remained significantly higher than in adults. TmPO4/GFR in the children correlated neither with fasting serum immunoreactive calcitonin and parathyroid hormone levels nor with the urinary cyclic AMP excretion. The study showed a parallel decrease in TmPO4/GFR, excretion of total hydroxyproline and serum alkaline phosphatase activities after puberty, with a significant relationship of both these indices of bone turnover to TmPO4/GFR values. This indicates that the high renal phosphate threshold of children may be an important factor for bone mineralisation by providing high extracellular inorganic phosphate concentrations during normal growth.

摘要

采用沃尔顿和比约弗特列线图，对546名年龄在6至17.9岁之间的学童测定了肾小管对磷酸盐最大重吸收率与肾小球滤过率的比值（TmPO4/GFR）。1 TmPO4/GFR与男孩和女孩的实际年龄相关，且在每个年龄段均显著高于成年人。儿童的TmPO4/GFR与空腹血清免疫反应性降钙素和甲状旁腺激素水平均无关联，与尿中环磷酸腺苷排泄也无关联。该研究表明，青春期后TmPO4/GFR、总羟脯氨酸排泄和血清碱性磷酸酶活性呈平行下降，骨转换的这两个指标与TmPO4/GFR值均存在显著关系。这表明，儿童较高的肾磷酸盐阈值可能是正常生长过程中通过提供高细胞外无机磷酸盐浓度促进骨矿化的一个重要因素。

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本文引用的文献

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