慢性普萘洛尔治疗可降低自发性高血压大鼠的心脏β-肾上腺素能受体。

Chronic propranolol treatment decreases cardiac beta-adrenoceptors in spontaneously hypertensive rats.

作者信息

Baker S P, Katovich M J

出版信息

Eur J Pharmacol. 1982 Mar 26;78(4):479-82. doi: 10.1016/0014-2999(82)90493-9.

Abstract

Spontaneously hypertensive (SHR) rats were treated for 6 months with 41.6 or 94.6 mg/kg per day of (+/-)-propranolol. Compared to untreated SHR rats, the heart rate and blood pressure in both treated groups were decreased. The cardiac beta-adrenoceptor concentration was similar in the untreated and low dose (+/-)-propranolol-treated group but was decreased by 30% after treatment with the high (+/-)-propranolol dose. The results suggest that high dose (+/-)-propranolol treatment reduces the cardiac beta-adrenoceptor concentration.

摘要

自发性高血压（SHR）大鼠每日接受41.6或94.6毫克/千克的（±）-普萘洛尔治疗6个月。与未治疗的SHR大鼠相比，两个治疗组的心率和血压均降低。未治疗组和低剂量（±）-普萘洛尔治疗组的心脏β-肾上腺素能受体浓度相似，但高剂量（±）-普萘洛尔治疗后该浓度降低了30%。结果表明，高剂量（±）-普萘洛尔治疗可降低心脏β-肾上腺素能受体浓度。