Kocsis J D, Waxman S G
Brain Res. 1982 Apr 22;238(1):222-7. doi: 10.1016/0006-8993(82)90787-9.
Intra-axonal recordings were obtained in the dorsal columns of the rat lumbosacral spinal cord. Dorsal root or dorsal column stimulation at levels subthreshold for the impaled axon elicited a prolonged depolarization corresponding to the primary afferent depolarization (PAD). The depolarization was preceded by a brief hyperpolarizing potential during which excitability was decreased. The hyperpolarization corresponds temporally to the extracellularly recorded DRP IV component of the dorsal root potential described by Lloyd and McIntyre, and may represent the intracellular correlate of this potential. Possible mechanisms for this hyperpolarization include electrical interactions between neuronal elements, a biphasic GABA response, or attenuation of background afferent axonal depolarization.
在大鼠腰骶脊髓的背柱中进行了轴突内记录。在低于被穿刺轴突阈值的水平刺激背根或背柱，引发了与初级传入去极化（PAD）相对应的长时间去极化。去极化之前有一个短暂的超极化电位，在此期间兴奋性降低。这种超极化在时间上与Lloyd和McIntyre描述的背根电位的细胞外记录DRP IV成分相对应，可能代表了该电位的细胞内相关物。这种超极化的可能机制包括神经元元件之间的电相互作用、双相GABA反应或背景传入轴突去极化的衰减。
