Katz A M
Fed Proc. 1982 Jun;41(8):2456-9.
Alterations in the function of cardiac cellular membranes may contribute to the pathogenesis of abnormal cardiac function after both acute and chronic administration of ethanol. Both the sarcolemmal sodium pump-derived Na+,K+-ATPase and the calcium pump of the sarcoplasmic reticulum are inhibited by ethanol, although inhibitory effects at concentrations that can be reached in humans are seen only under special conditions. Abnormalities in both the Na+,K+-ATPase and calcium pump have been observed after chronic ethanol ingestion, and there is evidence that chronic ethanol ingestion reduces the sensitivity of these activities to ethanol added in vitro. The acute effects of ethanol on these membrane activities appear to be related to an increase in membrane fluidity, whereas the altered functional state of membranes produced by chronic ethanol ingestion may reflect alterations in membrane lipids, possibly associated with a decrease in membrane fluidity.
急性和慢性摄入乙醇后，心肌细胞膜功能的改变可能促成心脏功能异常的发病机制。乙醇可抑制肌膜上由钠泵产生的Na +，K + -ATP酶以及肌浆网的钙泵，不过只有在特殊条件下才会出现对人体可达到浓度的抑制作用。长期摄入乙醇后，已观察到Na +，K + -ATP酶和钙泵均出现异常，并且有证据表明，长期摄入乙醇会降低这些活性对体外添加乙醇的敏感性。乙醇对这些膜活性的急性作用似乎与膜流动性增加有关，而长期摄入乙醇所产生的膜功能状态改变可能反映了膜脂质的变化，这可能与膜流动性降低有关。
