Yamamoto C
Exp Brain Res. 1982;46(2):170-6. doi: 10.1007/BF00237173.
The values of quantal content (m) and quantal amplitude (q) of excitatory postsynaptic potentials (EPSPs) elicited in CA3 neurons by activation of granule cells were estimated in thin hippocampal sections maintained in vitro. For this purpose, DL-homocysteate was administered to granule cells, and trains of EPSPs that were typical for single granule cell activation were recorded from individual CA3 neurons. The amplitudes of the first and second EPSPs in each train were measured. Fron the mean and variance of the amplitude of the EPSPs, the values of q and m were calculated. The values of m and q for the first EPSPs were estimated at 8.3 and 0.28 mV, respectively, on the average. Potentiation of the second EPSPs was accompanied by a two-fold increase in the values of m without changes in the values of q. Therefore, frequency potentiation in synapses between mossy fibers and CA3 neurons may be explained by an increase in number of released quanta. Amplitudes of EPSPs were found to fluctuate in a manner described by Poisson's law.
在体外维持的薄海马切片中，估计了颗粒细胞激活在CA3神经元中引发的兴奋性突触后电位（EPSP）的量子含量（m）和量子幅度（q）值。为此，将DL-高半胱氨酸施用于颗粒细胞，并从单个CA3神经元记录典型的单个颗粒细胞激活的EPSP序列。测量每个序列中第一个和第二个EPSP的幅度。根据EPSP幅度的均值和方差，计算q和m的值。第一个EPSP的m和q值平均分别估计为8.3和0.28 mV。第二个EPSP的增强伴随着m值增加两倍，而q值没有变化。因此，苔藓纤维与CA3神经元之间突触的频率增强可能是由于释放量子数量的增加所致。发现EPSP的幅度以泊松定律描述的方式波动。
